Posted: December 17, 2021
THE NEW NOVEL ANTICOAGULANTS XI(a) and XII(a). THE CONTACT FACTOR INHIBITORS: Battling thromboembolism. David L. McGlasson, MS, MLS(ASCP) INTRODUCTION Thromboembolism is a leading cause of mortality and morbidity. Treatment with anticoagulants is prescribed, but balancing bleeding and clotting has been a challenge. In the 1940s, unfractionated heparin (UFH) became available for use by intravenous or…
Posted: September 27, 2021
A Trio of Biomarkers: A Novel Multivariate Model to Detect DILI & Liver Damage -Contributed by Abi Kasberg, PhD While maybe underappreciated, Drug-induced liver injury (DILI) is a condition with significant impact on the medical world. DILI is the leading cause of acute liver failure and is frequently responsible for the termination and withdrawal of…
Posted: September 27, 2021
Clot Club – ISTH 2021 David L. McGlasson, MS, MLS(ASCP) Attending the International Society of Thrombosis and Hemostasis 2021 virtually from July 17-21, 2021 was quite a challenge this year. There were lots of information ranging from clinical, to what I would call “futuristic” research, that we might not see put into clinical practice for…
Posted: August 19, 2021
Thrombotic Thrombocytopenic Purpura (TTP) Clinical Trials: Targeting the needs left by current treatment options -Contributed by Abi Kasberg, PhD Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy blood disorder that is characterized by the formation of blood clots in small blood vessels, thrombocytopenia, and a lack of ADAMTS-13 (a disintegrin-like and metalloproteinase with thrombospondin…
Posted: July 8, 2021
In vitro Liver Culture Systems to Investigate DILI Contributed by Abi Kasberg, PhD An important function of the liver is to concentrate and metabolize drugs and xenobiotics, which makes the liver vulnerable to tissue damage. Drug-induced Liver Injury (DILI) is the onset of liver damage caused by drugs, medications, or supplements. DILI is associated with…