Go with the Pro – Intact Proinsulin for your Diabetes Research
Posted: December 8, 2021
When it comes to measuring pancreatic Beta cell function, go with the Pro!
TECO® Proinsulin ELISA
Why Measure Intact Proinsulin?
Proinsulin is the precursor of insulin and Connecting Peptide (C-Peptide). Following synthesis, proinsulin is packaged into secretory granules, where it is processed to C-Peptide and insulin by prohormone convertases (PC1/3 and PC2) and carboxypeptidase E.
Only 1% to 3% of proinsulin is secreted intact. However, because proinsulin has a longer half-life than insulin, circulating proinsulin concentrations are in the range of 5% to 30% of circulating insulin concentrations on a molar basis, with the higher relative proportions seen after meals and, in subjects with insulin resistance, MSY or early type 2 diabetes. Proinsulin can bind to the insulin receptor and exhibits 5% to 10% of the metabolic activity of insulin.
Save time by avoiding measuring Total Proinsulin with inactive insulin and breakdown products. Eliminate the guess work and be certain about what you are measuring!
Benefits of the TECO® Proinsulin ELISA:
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- Measures intact active Proinsulin only
- Only intact Proinsulin is a direct measure of pancreatic Beta-cell function
- The only ELISA standardized against WHO reference.
- Measures intact active Proinsulin only
- Reliable tool for research studies and clinical trials involving risk for Type 1 or Type 2 Diabetes and for Metabolic Syndrome research and drug development studies
Explore our additional diabetes research markers, including:
- Anti-GAD
- Anti-ZnT8
- Anti-IA2
Visit diapharma.com for our comprehensive portfolio.
For research use only in the U.S. and Canada. Not for use in diagnostic procedures.
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