Posted: August 19, 2021
Thrombotic Thrombocytopenic Purpura (TTP) Clinical Trials: Targeting the needs left by current treatment options -Contributed by Abi Kasberg, PhD Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy blood disorder that is characterized by the formation of blood clots in small blood vessels, thrombocytopenia, and a lack of ADAMTS-13 (a disintegrin-like and metalloproteinase with thrombospondin…
Posted: July 8, 2021
In vitro Liver Culture Systems to Investigate DILI Contributed by Abi Kasberg, PhD An important function of the liver is to concentrate and metabolize drugs and xenobiotics, which makes the liver vulnerable to tissue damage. Drug-induced Liver Injury (DILI) is the onset of liver damage caused by drugs, medications, or supplements. DILI is associated with…
Posted: May 19, 2021
Hypercoagulation During Sickle Cell Disease Contributed by Abi Kasberg, PhD Sickle cell disease (SCD) is a genetic hemoglobin disease that disrupts the ability of red blood cells (RBCs) to deliver oxygen throughout the body. RBCs are normally round and flexible, which allows them to flow easily through vasculature. However, in SCD, RBCs are crescent-shaped due…
Posted: April 29, 2021
CLOT CLUB David L. McGlasson, MS, MLS(ASCP) Lupus Anticoagulants/Antiphospholipid Antibodies/Antiphospholipid Antibody Syndrome Part II Testing for Antiphospholipid Antibody Syndrome Platelet-Poor Plasma (PPP) The quality of the patient’s PPP greatly affects the integrity of the testing. To obtain PPP, the capped citrated specimen is centrifuged at room temperature for at least 15 minutes at 1500–2500 Xg.…
Posted: March 29, 2021
CLOT CLUB David L. McGlasson, MS, MLS(ASCP) Lupus Anticoagulants/Antiphospholipid Antibodies/Antiphospholipid Antibody Syndrome Part I The late Douglas A. Triplett, MD, PhD, who was a colossal figure in the field of Coagulation, paraphrased Winston Churchill in describing a lupus anticoagulant/antiphospholipid antibody as: “a riddle, wrapped in a mystery, inside an enigma.” In other words, a difficult…
Posted: March 15, 2021
– Contributed by Abi Kasberg, PhD Hemoglobins are protein molecules found in red blood cells (RBCs) that functionally transport oxygen from the lungs to the cells of the body and to shuttle carbon dioxide back to the lungs. Hemoglobins also play important roles in maintaining RBC shape by dynamically changing conformation through binding oxygen.…