Haematex DOAC-Stop L (Liquid) 2mL (100 tests)

Just like DOAC-Stop, but faster, better, and stronger. DOAC-Stop™ L is a liquid formulation of the DOAC-Stop mini and micro tabs, made for instant dispersion in samples.

DOAC-Stop™ L mixes with plasma more rapidly and works in less than five minutes.

As with the entire DOAC-Stop line, DOAC-Stop Liquid extracts DOACs from test plasma with minimal effect on underlying clotting mechanisms, allowing further analysis of the sample.

2mL vial is stable for three (3) years when stored at 2-8°C.

DOAC-Stop-L™ can be used to efficiently remove all types of Direct Oral Anti-Coagulants (DOACs) including dabigatran, apixaban, rivaroxaban and edoxaban, from test plasmas with minimal effect on plasma proteins involved in the clotting mechanism.

DOAC-Stop-L™ can be used to identify plasmas containing DOACs using simple clotting tests. DOAC-Stop-L™ is an adsorbent product that extracts DOACs from plasmas.

Limitations

DOAC-Stop-L™ may extract low molecular weight compounds resembling DOACs from plasmas. Those affecting coagulation (but administered intravenously, not orally) include argatroban, aprotinin, protamine, hirudin analogues, polymyxin and related cationic compounds.

Precautions

DOAC-Stop-L™ is intended for use with plasma samples suspected to contain DOACs. If test results are unchanged by DOAC-Stop-L™ and DOACs are still suspected to be present, apply appropriate chromogenic anti-Factor Xa or anti-Factor IIa assays to obtain specific DOAC results. Contact Diapharma for product info and technical support.

Store in a dry area at room temperature. Do not use after the expiry date indicated on the label. Treat all material as potentially infectious and dispose in accordance with local operating regulations. For further information, please refer to Safety Data Sheet and Product Information.

For Research Use Only in the US and Canada. Not for use in diagnostic procedures.

Background

DOACs are known to interfere with almost all clotting tests to varying degrees. Thus, in the coagulation research laboratory, plasmas giving unexpectedly prolonged clotting time or abnormal chromogenic test results may need to be screened for the presence of DOACs. Sometimes study subjects to be tested for underlying coagulation defects may also be on DOACs. DOAC-Stop™ is the first general agent available for solving the interference problems associated with DOACs. After treatment with DOAC-Stop™, plasma samples can be analyzed for factor deficiencies, heparin, lupus anticoagulant, or other interfering antibodies.

Just add 20uL DOAC-Stop liquid per 1.0mL citrated test plasma, mix for 5 minutes and centrifuge down the particulate matter. The resulting plasma is then depleted of DOACs and yields similar APTT, dRVVT, PT(INR) and other results as if DOACs had not been present.

May be useful for identifying if DOACs are present and, also for providing DOAC free plasmas for valid testing of a range of hemostatic parameters in test plasma. It leaves no residual effect. It can be used for checking if DOACs are present in samples giving unexpectedly prolonged clotting test or abnormal chromogenic test results.

There is negligible interference with vitamin K antagonist or heparinoid anticoagulants. Plasmas treated with DOAC-Stop™ can be used for valid factor assays and in thrombosis research.