Respiratory Research Solutions from DiaPharma

Posted: May 16, 2022

It’s Not Just Support. It’s Solutions.


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DiaPharma is Your Exclusive Source for ProAxsis products

 

ProteaseTag


ProteaseTag


Reach out to DiaPharma’s Olivia Stricker, who will be at

American Thoracic Society (ATS) 2022 in San Francisco, May 13 – 16.

Diapharma Olivia Stricker

Elevate your clinical research data by measuring active proteases

Targets:

Drug development evaluating new protease inhibitors or anti-inflammatory therapies for Cystic Fibrosis, Bronchiectasis, COPD and alpha 1 antitrypsin (AAT) deficiency.

Active Neutrophil Elastase (NE) and Proteinase 3 (PR3) are serine proteases that have been shown to correlate with the severity of disease, bacterial exacerbations, and inflammation.

Benefits:

ProteaseTag™ Technology enables you to target only the active form of the protease, thus providing a stronger correlation with disease status and pathogenic activity than assays that measure total protease levels. Ultimately, this provides an accurate quantitative assessment of changes in the inflammatory state of the lung over time as an endpoint.

ProteaseTag™ Active NE Immunoassay meets the need for a robust assay to measure the active biomarker – it’s the only assay that can detect active proteases with a standard microplate reader, without utilizing chromogenic or fluorogenic substrates.

Learn more about the assays ProAxsis offers and the ProteaseTag™ technology at diapharma.com.

ProteaseTag® Technology

ProteaseTag

ProteaseTag


Learn more about DiaPharma’s complimentary portfolio of products for pulmonary research

Biomarker Significance in Lung Studies Product Packaging Use Catalog #
Cytokeratin 18

Expressed in epithelial cells of the lung.

Increases detected in lung damage or infection.

Apoptosis assay-caspase readout.

M30 Apoptosense® CK18 ELISA Kit Kit/96 tests RUO P10011
M65® ELISA CK18 ELISA Kit Kit/96 tests RUO P10020
M65 EpiDeath® CK18 ELISA Kit Kit/96 tests RUO P10040
M30 CytoDeath CK18 ELISA Kit Kit/96 tests RUO P10900
Periostin

Secreted by activated fibroblasts and promotes fibrosis.

Correlates with pulmonary function decline and disease progression in IPF.

FluoBolt Periostin Immunoassay Kit Kit/96 tests RUO FIA-1703
Soluble CD163

Soluble macrophage marker.

Increases in inflammatory conditions.

IQ Macro163 ELISA Kit Kit/96 tests RUO IQP-383
Neutrophil
Elastase (NE)

Degradative enzyme released by activated neutrophils.

Increases reported as indication of inflammation and tissue damage.

ProAxsis ProteaseTag® NE Activity Kit Kit/96 tests RUO PA001US
ProAxsis NEATstik® Rapid NE Activity Test Box is 10 tests RUO PA004-10US
ImmunoDiagnostics NE ELISA kit Kit/96 tests RUO 31330
Proteinase 3
(PR3)

Degradative enzyme released by activated neutrophils.

Increases reported as indication of inflammation and tissue damage.

ProAxsis ProteaseTag® PR3 Activity Kit Kit/96 tests RUO PA008US
ImmunoDiagnostics PR3 ELISA Kit Kit/96 tests RUO 31300
Alpha 1 Antitrypsin
(AAT)

Inhibitor of neutrophil elastase enzyme.

Decreases in AAT protein cause disease of the lung and liver. (Alpha-1 Antitrypsin Deficiency)

ImmunoDiagnostics A1AT ELISA Kit Kit/96 tests RUO 31420
Urokinase-type plasminogen activator (uPA) Inflammatory and fibrinolysis marker, specific to lung tissue Technozym® uPA Combi Actibind® ELISA Kit Kit/96 tests RUO TC16010

Diapharma Pulmonary Research Products

All products are for research use only. Not for use in diagnostic procedures.

It’s Not Just Support. It’s Solutions.

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with support just a call or click away.

Diapharma Technical Support


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