Respiratory Research Solutions from DiaPharma
Posted on: May 16, 2022
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DiaPharma is Your Exclusive Source for ProAxsis products
Reach out to DiaPharma’s Olivia Stricker, who will be at
American Thoracic Society (ATS) 2022 in San Francisco, May 13 – 16.
Elevate your clinical research data by measuring active proteases
Targets:
Drug development evaluating new protease inhibitors or anti-inflammatory therapies for Cystic Fibrosis, Bronchiectasis, COPD and alpha 1 antitrypsin (AAT) deficiency.
Active Neutrophil Elastase (NE) and Proteinase 3 (PR3) are serine proteases that have been shown to correlate with the severity of disease, bacterial exacerbations, and inflammation.
Benefits:
ProteaseTag™ Technology enables you to target only the active form of the protease, thus providing a stronger correlation with disease status and pathogenic activity than assays that measure total protease levels. Ultimately, this provides an accurate quantitative assessment of changes in the inflammatory state of the lung over time as an endpoint.
ProteaseTag™ Active NE Immunoassay meets the need for a robust assay to measure the active biomarker – it’s the only assay that can detect active proteases with a standard microplate reader, without utilizing chromogenic or fluorogenic substrates.
Learn more about the assays ProAxsis offers and the ProteaseTag™ technology at diapharma.com.
ProteaseTag® Technology
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Learn more about DiaPharma’s complimentary portfolio of products for pulmonary research
| Biomarker | Significance in Lung Studies | Product | Packaging | Use | Catalog # |
| Cytokeratin 18 |
Expressed in epithelial cells of the lung. Increases detected in lung damage or infection. Apoptosis assay-caspase readout. |
M30 Apoptosense® CK18 ELISA Kit | Kit/96 tests | RUO | P10011 |
| M65® ELISA CK18 ELISA Kit | Kit/96 tests | RUO | P10020 | ||
| M65 EpiDeath® CK18 ELISA Kit | Kit/96 tests | RUO | P10040 | ||
| M30 CytoDeath™ CK18 ELISA Kit | Kit/96 tests | RUO | P10900 | ||
| Periostin |
Secreted by activated fibroblasts and promotes fibrosis. Correlates with pulmonary function decline and disease progression in IPF. |
FluoBolt™ Periostin Immunoassay Kit | Kit/96 tests | RUO | FIA-1703 |
| Soluble CD163 |
Soluble macrophage marker. Increases in inflammatory conditions. |
IQ Macro163™ ELISA Kit | Kit/96 tests | RUO | IQP-383 |
| Neutrophil Elastase (NE) |
Degradative enzyme released by activated neutrophils. Increases reported as indication of inflammation and tissue damage. |
ProAxsis ProteaseTag® NE Activity Kit | Kit/96 tests | RUO | PA001US |
| ProAxsis NEATstik® Rapid NE Activity Test | Box is 10 tests | RUO | PA004-10US | ||
| ImmunoDiagnostics NE ELISA kit | Kit/96 tests | RUO | 31330 | ||
| Proteinase 3 (PR3) |
Degradative enzyme released by activated neutrophils. Increases reported as indication of inflammation and tissue damage. |
ProAxsis ProteaseTag® PR3 Activity Kit | Kit/96 tests | RUO | PA008US |
| ImmunoDiagnostics PR3 ELISA Kit | Kit/96 tests | RUO | 31300 | ||
| Alpha 1 Antitrypsin (AAT) |
Inhibitor of neutrophil elastase enzyme. Decreases in AAT protein cause disease of the lung and liver. (Alpha-1 Antitrypsin Deficiency) |
ImmunoDiagnostics A1AT ELISA Kit | Kit/96 tests | RUO | 31420 |
| Urokinase-type plasminogen activator (uPA) | Inflammatory and fibrinolysis marker, specific to lung tissue | Technozym® uPA Combi Actibind® ELISA Kit | Kit/96 tests | RUO | TC16010 |
All products are for research use only. Not for use in diagnostic procedures.
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