Endotyping for Clinical Trial Success with COPD, bronchiectasis, asthma

Posted: September 29, 2022

It’s Not Just Support. It’s Solutions.

Neutrophil Elastase Activity Immunoassay

Endpoints for clinical trials in lung disease could be better…

Neutrophil Elastase Activity Immunoassay

  • FEV1 and FVC are relatively blunt tools for getting a complete picture of a disease state – they do not provide information on the pulmonary microenvironment.
  • Inflammation is a hallmark of chronic lung diseases and an important piece of the bigger picture to understand when evaluating effectiveness of a drug
  • Decreasing lung-specific inflammation is a key strategy for pharmaceutical targets
  • Mechanistic markers of inflammation, such as these, can be detected earlier and indicate sub-clinical improvements in outcomes which help drive decision making during the drug design and clinical trial process

ADD DETAIL to a drug’s storyline with accurate and lung-specific measurements of inflammation by measuring neutrophil elastase (NE) and proteinase 3 (PR3) in sputum.

ProAxsis offers products that are proven to be valuable in enrolling participants, stratifying results, and measuring effectiveness of respiratory drugs in development. The ready- to -use kits offer sensitive, reliable, and accurate read-outs of NE and PR3 activity in sputum or broncheoalveolarlavage (BAL) fluid. NE and PR3 activity levels have been shown to correlate with disease severity, time to next exacerbation, and bacterial load. They can be more globally seen as mechanistic markers of a neutrophilic-driven inflammatory state.

DiaPharma offers assays from ProAxsis using ProteaseTag™ technology:

For research use only. Not for use in diagnostic procedures.

Neutrophil Elastase Activity Immunoassay

Learn more about DiaPharma’s complimentary portfolio of products for pulmonary research

Diapharma Pulmonary Research Products

It’s Not Just Support. It’s Solutions.

Celebrating 25 years of scientific expertise,
with support just a call or click away.

Connect with a DiaPharma Scientist

diapharma bioassays hemostasis thrombosis chromogenic


Copyright © 2022 DiaPharma Group, Inc. All rights reserved.

DiaPharma Group, Inc. 8948 Beckett Rd, West Chester, OH 45069

Technical Support: 1.800.447.3846