Because matrix matters! The path to lung disease is paved with MMPs and collagen

Posted: December 14, 2022

It’s Not Just Support. It’s Solutions.


DiaPharma and QuickZyme Know Matrix Matters!

QuickZyme specializes in collagen assays and MMP activity assays (MMP-2, MMP-7, MMP-8, MMP-9, MMP-14). These assays were developed by scientists to fill an unmet need as an alternative to laborious methods. The assays give a more granular insight to the role that extracellular matrix remodeling can play in fibrosis, inflammation, and metastatic tumors.

MMPs degrade collagen, elastin, and proteoglycans. As indicators of inflammation and disease, they are key targets for drug development.

  • Idiopathic pulmonary fibrosis (IPF): MMP-7 plays a role in the development of scarring in the lungs and may predict a decline of lung function.
  • Chronic obstructive pulmonary disease (COPD): Circulating MMP-9 is linked with increased exacerbation risk.
  • Cystic fibrosis (CF): MMP-7, MMP-8, and MMP-9 may play an important role in the injury/repair response in CF.
  • Lymphangioleiomyomatosis (LAM): MMP-2 and MMP-7 are expressed and contribute to the destruction of lung tissue in LAM.
  • Cigarette smoke: MMP-1, -2, -7, -9 and -12 have all been implicated in tissue damage due to cigarette smoke, but MMP-12 has been the most extensively studied.

Finally, a test to accurately and specifically quantify MMP activity in relevant biological samples (blood, sputum, urine, cell cultures, etc.). These kits make testing more efficient, with a dual readout option: Measure endogenous active (naturally occurring) or total (active + pro) MMP for each plate.


Learn More

Make your life easier with these QuickZyme MMP Activity Assays:

Research use only in the U.S. and Canada. Not for use in diagnostic procedures.

More to Explore

DiaPharma offers an extensive portfolio of pulmonary biomarkers, including Cytokeratin 18 (CK18, K18) ELISAs – M30® and M65®, ProAxsis Neutrophil Elastase Activity Kit, IMD Neutrophil Elastase ELISA Kit, ProAxsis Proteinase 3 Activity Kit, IMD Proteinase 3 ELISA kit, Quickzyme Total Collagen Kit, IMD Alpha 1 Antitrypsin (A1AT), and IQ Macro163™ ELISA.



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