Because matrix matters! The path to liver disease is paved with MMPs and collagen

Posted: November 11, 2022

It’s Not Just Support. It’s Solutions.


DiaPharma and QuickZyme Know Matrix Matters!

Matrix Metalloproteases (MMPs) degrade collagen and elastin. As indicators of inflammation and disease, they are key targets for drug development.

  • Biliary Atresia MMP-7 has garnished much research support for its role in mediating biliary injury in the disease.
  • NAFLD/NASH Serum MMP-7 can further research of advanced fibrosis. MMP-9 is useful when researching NAFLD.
  • ALD Publications show that MMP-2, MMP-8 and MMP-9 may be markers of alcohol-associated liver cirrhosis. Also, pre-clinical rat models show that MMP-9 is elevated when exposed to chronic alcohol consumption.

QuickZyme specializes in collagen-related assays and MMP activity assays (MMP-2, MMP-7, MMP-8, MMP-9, MMP-14). These assays were developed by scientists to fill an unmet need in their studies. They give a more granular insight to the role that fabrication and degradation of the extracellular matrix can play in fibrosis, inflammation, and metastatic tumors.

Finally, a test to accurately and specifically quantify MMP activity in relevant biological samples (blood, sputum, urine, cell cultures, etc.). These kits make testing more efficient, with a dual readout option: Measure endogenous active MMP-7 (naturally occurring) or total (active + pro) MMP-7 for each plate.



Available QuickZyme MMP Activity Assays:

Make your life easier with these QuickZyme kits.

Research use only in the U.S. and Canada. Not for use in diagnostic procedures.

More to Explore

DiaPharma offers an extensive portfolio of liver biomarkers, including Cytokeratin 18 (CK18, K18) ELISAs – M30® and M65®, Liver-FABP (FABP1), TSP-2, GDF-15, Adiponectin, FGF-21, Neutrophil Elastase, Adipocyte-FABP (FABP4), Osteopontin, Quickzyme Total Collagen.



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