Go further than FEV1 and FVC – Mechanistic Biomarkers for Lung Disease

Posted: October 11, 2022

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Neutrophil Elastase Activity Immunoassay

A Case for Letting Endotype Lead the Way in Drug Development…

 

Endotype

Neutrophilic VS Eosinophilic
Neutrophilic      VS      Eosinophilic

The molecular mechanisms that drive chronic lung disease are heterogenetic. To evolve past a “one drug fits all approach”, toward a more individualized and precision approach, pharmaceutical companies are focusing on drugs that can address each etiology within a disease. These subtypes of mechanistic drivers or pathobiology, endotypes, have come to the forefront in drug design. An endotype approach is therefore important for selecting targets for drug development and deployment.

  • COPD, bronchiectasis, and asthma are typically endotyped as eosinophilic or neutrophilic
  • Neutrophilic driven disease is indicated by high activity of neutrophil proteases, neutrophil elastase (NE), or proteinase 3 (PR3)
  • Neutrophil elastase activity measurement offers a way to better select targets for drug development aimed at neutrophil-specific pathways

Neutrophil Elastase Activity Immunoassay

DiaPharma offers assays from ProAxsis using ProteaseTag™ technology:

For research use only. Not for use in diagnostic procedures.


Learn more about DiaPharma’s complimentary portfolio of products for pulmonary research

Diapharma Pulmonary Research Products


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