Go further than FEV1 and FVC – Mechanistic Biomarkers for Lung Disease
Posted on: October 11, 2022
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It’s Not Just Support. It’s Solutions.
A Case for Letting Endotype Lead the Way in Drug Development…
Neutrophilic VS Eosinophilic
The molecular mechanisms that drive chronic lung disease are heterogenetic. To evolve past a “one drug fits all approach”, toward a more individualized and precision approach, pharmaceutical companies are focusing on drugs that can address each etiology within a disease. These subtypes of mechanistic drivers or pathobiology, endotypes, have come to the forefront in drug design. An endotype approach is therefore important for selecting targets for drug development and deployment.
- COPD, bronchiectasis, and asthma are typically endotyped as eosinophilic or neutrophilic
- Neutrophilic driven disease is indicated by high activity of neutrophil proteases, neutrophil elastase (NE), or proteinase 3 (PR3)
- Neutrophil elastase activity measurement offers a way to better select targets for drug development aimed at neutrophil-specific pathways
DiaPharma offers assays from ProAxsis using ProteaseTag™ technology:
- Neutrophil Elastase (NE) Activity Immunoassay – quantitative 96-well kit
- Proteinase 3 (PR3) Immunoassay – quantitative 96-well kit
- NEATstik Neutrophil Elastase – semi-quantitative lateral flow kit
For research use only. Not for use in diagnostic procedures.
Learn more about DiaPharma’s complimentary portfolio of products for pulmonary research
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