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Technozym® ADAMTS-13 ELISA is a Fluorogenic ELISA kit for the determination of ADAMTS-13 activity and antigen concentration in human plasma. ADAMTS-13 is the enzyme that cleaves vWF under laminar flow conditions. A functional defect of this enzyme leads to the presence of higher molecular weight forms of vWF and thus to increased platelet aggregation, mainly in the microvasculature.
ELISA test strips | (2×6 for 2x48T), with 8 wells each, coated with a monoclonal anti ADAMTS13, directed against the CUB domain; the drying agent is supplied in an aluminium bag. |
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Washing buffer concentrate | (PBS; pH 7.3); containing detergent; 0.01% merthiolate; 1 vial, 100 mL. |
Incubation buffer | (PBS; pH 7.3); contains stabiliser protein; 0.01% merthiolate; and dye, 1 vial, 100 mL, ready for use. |
Calibrators | (standards) numbered from 1 to 5; lyophilised; 1 vial each; 0.5 mL. Concentrations are lot-specific; consult the label on the vial or the included batch table. |
High and low control plasma | lyophilised; 1 vial each; 0.5mL. Concentrations are lot-specific; consult the label on the vial. |
Activity substrate | 2 vials for 2x48T.; 3 mL each, lyophilised. |
Conjugate | anti-ADAMTS-13 POX; dyed blue; 1 vial, 0.3 mL. |
Antigen substrate | 1 vial, 6 mL. |
Stable peroxide solution | 1 vial, 0.7mL. |
Stop solution for antigen substrate | 1 vial; 6 mL; ready to use. |
Adhesive film | for ELISA test strips; 2 pieces. |
See Graphic
ADAMTS-13
ADAMTS-13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13) is an enzyme (vWF-cleaving protease or vWF-CP) that specifically cleaves von Willebrand Factor (vWF) multimers.