Address Unmet Needs in Type 1 Diabetes Drug Development with These Biomarkers
Posted on: April 11, 2023
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How can blood-based biomarkers enrich your Type 1 Diabetes (T1D) study population?
In individuals at high risk for Type 1 Diabetes (T1D), the presence of two or more islet auto-antibodies (AAs), such as those to insulin, GAD65, IA-2, and ZnT8, has been shown to be predictive of the rate of disease progression. These islet AAs can be used together with other features to help identify individuals at highest risk for disease development.
In trials intended to prevent or delay the clinical diagnosis of T1D, including these biomarkers in the enrollment process can therefore aid in enriching the study population with subjects likely to progress to stage 3 disease within a reasonable time span. This may allow for smaller and shorter trials, leading to potential cost savings for the study sponsors.
Leading Expertise in Type 1 Diabetes Research Assays
DiaPharma offers ELISAs from our partner Medipan GmbH for determination of islet AAs in human serum samples.
- Medizym® Anti- GAD (35071) – antibodies against glutamic decarboxylase (GAD65)
- Medizym® Anti- IA2 (35061) – antibodies against protein tyrosine phosphatase (insulinoma antigen-2, IA-2)
- Medizym® IAA (38061) – IgG antibodies against insulin
These quantitative assays are easy to perform, and provide reproducible and reliable results.
- Convenient: Ready-to-use, color- and barcoded reagents
- Incubation at room temperature
- Results expressed in IU/mL
- Excellent sensitivity and specificity
- High precision within the measurement range
- Fully automatable
Also available exclusively in North America from DiaPharma, TECO® Intact Proinsulin ELISA – Go with the Pro! Save time and guess work by selectively measuring only intact proinsulin.
All products are for research use only in the U.S. and Canada. Not for use in diagnostic procedures.
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