News from the front lines at SOT 2022: Checkpoint Inhibitor Liver Toxicity
Posted: June 7, 2022
It’s Not Just Support. It’s Solutions.
Spotlight on Liver Toxicity:
Immune-mediated Liver Injury
Caused by Checkpoint Inhibitors (ILICI)
One thing that jumped out at the Society of Toxicology (SOT) meeting this past March was a new phase of liver toxicology research focused on therapies that have a direct effect on immune function, specifically, hepatotoxicity related to the use of immune checkpoint inhibitors for treating cancer.
DiaPharma considers the complexities and outstanding research questions around Immune-mediated Liver Injury caused by Checkpoint Inhibitors (ILICI) in our blog post.
- Checkpoint inhibitor use is a successful new generation of cancer therapy, but can cause liver toxicity – as high as 10% in some cases
- The mechanism of liver toxicity is under investigation, but is not thought to be a result of toxic metabolites or direct hepatocyte toxicity
- There is a need for in-depth research into ILICI pathophysiology, and better liver injury biomarkers for liver toxicity.
Keratin 18 (K18) has potential to be a useful tool in understanding the role hepatocyte cell death plays in Immune-Mediated Liver Injury caused by Checkpoint Inhibitors (ILICI). For the drug development process, it can provide more liver-specific and earlier signals than ALT or AST. DiaPharma offers K18 and ccK18 assays, highly specific biomarkers for hepatocyte cell death.
M65® ELISA ● M65® EpiDeath ELISA ● M65® EpiRat ELISA ●
Learn about our extensive line of mechanistic biomarker assays for drug development and drug safety studies.
Our knowledgeable scientists are happy to discuss liver and kidney injury biomarker assays, featuring Keratin 18 (K18/CK18), L-FABP, α-GST, NGAL, Osteopontin, and Cystatin C.
For research use only. Not for use in diagnostic procedures.
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