Improve Early DILI/DIKI Prediction Increased Tissue Specificity
- K18 (M65®)
- ccK18 (M30®)
- L-FABP
- α-GST
- NGAL/Lipocalin-2
- Osteopontin
- Cystatin C
- α-Klotho
ELISAs for Drug-Induced Liver Injury (DILI)
| Biomarker | Sample Type | Description | Available Assay | Product # |
| Keratin 18 (K18) | Serum or plasma | Highly specific biomarker for hepatocyte cell death (necrosis and apoptosis) | Peviva M65® ELISA
Peviva M65 EpiDeath® ELISA | P10020
P10040 |
| Caspase-cleaved Keratin 18 (ccK18) | Serum or plasma | Highly specific specific biomarker for hepatocyte apoptosis | Peviva M30 Apoptosense® | P10011 |
| Osteopontin (OPN) | Serum or plasma | Biomarker for hepatic inflammation and necrosis | Osteopontin
Osteopontin N-Half | DPG27158
DPG27258 |
| Alpha Glutathione S-Transferase (a-GST) | Serum or plasma | Short half-life; sensitive to rapid changes in liver damage | TECO® Alpha GST | TE1056 |
| Liver Fatty Acid Binding Protein (L-FABP, FABP1) | Serum or plasma | Sensitive marker for hepatic injury (leakage) | Diapharma L-FABP | DPGLFABP |
ELISAs for Drug-Induced Kidney Injury (DIKI)
| Serum, plasma, or, urine | Sample Type | Description | Available Assay | Product # |
| Alpha Glutathione S-Transferase (α-GST) | Urine | Biomarker for proximal tubule damage | TECO® Alpha GST | TE1056 |
| Osteopontin (OPN) | Urine | Biomarker for damage to loop of Henle and distal tubule | Osteopontin
Osteopontin N-Half | DPG27158
DPG27258 |
| Liver Fatty Acid Binding Protein (L-FABP, FABP1) | Urine | Marker of acute kidney injury; useful for early detection of renal damage accompanying tubular dysfunction | Urinary L-FABP (FABP1) | 006 |
| Cystatin C (Cys C) | Serum, plasma or, urine | Assay for estimation of the glomerular filtration rate (GFR); more sensitive than serum creatinine tests | IMD Rapid Cystatin C | 31241 |
| Neutrophil Gelatinese-Associated Lipocalin (NGAL) | Urine | Biomarker for distal tubular | Diapharma NGAL (96)
Diapharma NGAL (2 x 96) IMD Lipocalin-2 | DPG-NGAL
DPG-2NGAL 31050 |
| Alpha Klotho (α-Klotho) | Plasma | Biomarker of impaired renal function, cytoprotective | FluoBolt™ α-KLOTHO (MEF-FIA) | FIA-1704 |