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Technoplastin® HIS (HIS = Heparin Insensitive) is a plain prothrombin time (PT) reagent according to the method of Quick. The reagent is lyophilized and contains rabbit brain thromboplastin and added calcium. Technoplastin® HIS is sensitive to decreased factors II, V, VII, X and fibrinogen levels but insensitive to heparin. Technoplastin® HIS is a “low” ISI-reagent with an ISI of about 1.2. Technoplastin® HIS can be used both as a test for the extrinsic coagulation system, as a liver function research test and for control of oral anticoagulants.”