Technochrom® Protein C
$0.00
Technochrom® Protein C (s100: Technochrom® Protein C (for Ceveron® alpha) is a Reagent Kit for chromogenic determination of protein C activity. The kit includes 3 standards, Protein C activator (Protac®), Protein C-substrate and Protein C buffer.
Protein C is activated by a specific activator and measured by its amydolytic activity on a specific chromogenic substrate.
- 3 x 1ml Substrate PCa-2
- 3 x 1ml Protein C Activator
- 1 x 60ml Protein C Buffer
- 3 x 1ml Standards (~0.25-1.25U/ml)
Features
- Assay linearity 0 -125%
- 3 reference standards
- High reagent stability
- Excellent accuracy and precision
- Economical use
Measurement Principle
| (Protac®) | ||
| Protein C | ————→ | Protein Ca |
| (Protein Ca) | ||
| Pad-Pro-Arg-pNA · AcOH | ————→ | Pad-Pro-Arg-OH · AcOH+p-nitroaniline |
Background
Protein C is a vitamin K dependent serine protease which, when activated, inhibits coagulation by inactivating the clotting factors V/Va and VIII/VIIIa. Additionally, protein C has been shown to have profibrinolytic activity. Hereditary, heterozygous protein C deficiency has been found to be associated with an increased risk of venous thrombosis and hereditary, homozygous total protein C deficiency has been found in neonates with purpura fulminans. Reduced levels of protein C have been found in association with vitamin K deficiency and coumarin.
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