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Technoclone Lupus Anticoagulant Test is a reagent kit for determination of Lupus inhibitor. Modified aPTTs are performed in using two different phospholipid concentrations each in a plasma exchange assay of the plasma sample with normal plasma.
Lupus inhibitors directed against platelet factor III (phospholipids) can be detected by means of a modified activated partial thromboplastin time (aPTT). In the test an activator of SiO2/AI2O3 suspension and two phospholipid concentrations are used. The modified aPTT’s are performed with normal plasma (free from platelet contamination), with patient plasma and with a mixture of both plasmas. From the shape of the “aPTT against plasma concentration” curve the probability of the presence of lupus inhibitor can be assessed.
| Reagent A | 1 x 3, phospholipid |
|---|---|
| Reagent B | 2 x 3, SiO2/AI2O3-suspension |
| Reagent C | 2 x 2, platelet poor normal plasma |
| Lupus Inhibitor plasma low | 1 x 1, positive control |
Lupus Inhibitor Plasma Low is prepared from selected lupus inhibitor plasma positive in most Lupus Inhibitor screening and confirmatory assays. Lupus Inhibitor Plasma contains stabilizers but no bactericide additives.