Chromogenix S-2403™ is a chromogenic substrate for plasmin and streptokinase-activated plasminogen.
Each vial contains the chromogenic substrate S-2403™ 25 mg and mannitol 60 mg as a bulking agent. Stability: Substance: Stable until expiry date if stored at 2-8°C. Avoid exposure to light. The substance is hygroscopic and should be stored dry. Solution: 7.5 mmol/L in H2O is stable for at least 6 months at 2 to 8°C.
Chemical name: L-Pyroglutamyl-L-Phenylalanyl-L-Lysine-p-Nitroaniline hydrochloride.
Mol. wt: 561.0
The method for the determination of activity is based on the difference in absorbance (optical density) between the pNA formed and the original substrate. The rate of pNA formation, i.e. the increase in absorbance per second at 405 nm, is proportional to the enzymatic activity and is conveniently determined with a photometer.