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Improve Early DILI/DIKI Prediction Increased Tissue Specificity |
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ELISAs for Drug-Induced Liver Injury (DILI) |
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| Biomarker | Sample Type | Description | Available Assay | Product # |
| Keratin 18 (K18) | Serum or plasma | Highly specific biomarker for hepatocyte cell death (necrosis and apoptosis) |
Peviva M65® ELISA Peviva M65 EpiDeath® ELISA |
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| Caspase-cleaved Keratin 18 (ccK18) | Serum or plasma | Highly specific specific biomarker for hepatocyte apoptosis | Peviva M30 Apoptosense® | P10011 |
| Osteopontin (OPN) | Serum or plasma | Biomarker for hepatic inflammation and necrosis |
Osteopontin Osteopontin N-Half |
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| Alpha Glutathione S-Transferase (a-GST) | Serum or plasma | Short half-life; sensitive to rapid changes in liver damage | TECO® Alpha GST | TE1056 |
| Liver Fatty Acid Binding Protein (L-FABP, FABP1) | Serum or plasma | Sensitive marker for hepatic injury (leakage) | Diapharma L-FABP | DPGLFABP |
ELISAs for Drug-Induced Kidney Injury (DIKI) |
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| Biomarker | Sample Type | Description | Available Assay | Product # |
| Alpha Glutathione S-Transferase (α-GST) | Urine | Biomarker for proximal tubule damage | TECO® Alpha GST | TE1056 |
| Osteopontin (OPN) | Urine | Biomarker for damage to loop of Henle and distal tubule |
Osteopontin Osteopontin N-Half |
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| Liver Fatty Acid Binding Protein (L-FABP, FABP1) | Urine | Marker of acute kidney injury; useful for early detection of renal damage accompanying tubular dysfunction | Urinary L-FABP (FABP1) | 006 |
| Cystatin C (Cys C) | Serum, plasma or, urine | Assay for estimation of the glomerular filtration rate (GFR); more sensitive than serum creatinine tests | IMD Rapid Cystatin C | 31241 |
| Neutrophil Gelatinese-Associated Lipocalin (NGAL) | Urine | Biomarker for distal tubular |
Diapharma NGAL (96) Diapharma NGAL (2 x 96) IMD Lipocalin-2 |
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| Alpha Klotho (α-Klotho) | Plasma | Biomarker of impaired renal function, cytoprotective | FluoBolt™ α-KLOTHO (MEF-FIA) | FIA-1704 |
Questions about any product in our lineup?We’re just a click or phone call away.800.526.5224 | info@diapharma.com | diapharma.com |
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| *Research use only in the U.S. and Canada. Not for diagnostic procedures. | ML-00-00518Rev01 |