Vitronectin Quick Facts

  • Molecular mass: 78 000 D
  • Synthesis: Liver
  • Plasma concentration: 250 – 450μg/ml
  • Normal range: 70 – 130%

Biochemistry of Vitronectin

Vitronectin (VTN) belongs to the pexin family. It is a multifunctional glycoprotein, that can be found in plasma and in the serum of the extracellular matrix. Vitronectin supports cell adhesion reactions in the coagulation and immune system. It inhibits the membrane damaging effect of the cytolytic complement system cascade and binds various serpins (e.g. PAI-1). By forming a binary complex with PAI-1, it can also directly regulate its enzyme activity.

Clinical significance of Vitronectin

A reduced plasma concentration of vitronectin can, for instance, be found in disseminated intravascular coagulation or degenerative liver diseases. Depositions of vitronectin are linked to atherosclerotic lesions.

Clinical or Research use of Vitronectin

Scientific investigations of different mechanisms or medical properties.

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