The Total Thrombus formation Analysis System (TTAS) is an automated microchip flow chamber system used to quantify the process of thrombus formation under blood flow conditions. The TTAS01 enables the ex vivo evaluation of overall hemostatic ability that more closely resembles in vivo conditions than other methodologies.
Technology Behind TTAS
The TTAS01 measures multiple integrated physical and physiologic properties of collagen and shear force stimulated platelets through the formation of the platelet plug. The TTAS01 measures the pressure differential over time across the test flow channel. In this method, the patient sample is flowed through the collagen coated test channels. As the platelets, adhere, activate, and aggregate to the walls of the microfluidic channels, the channels begin to occlude and the pressure builds. This building pressure is measured and displayed by highly sensitive pressure sensors in real time.
The PL chip for TTAS is designed for the diagnosis of primary hemostasis deficiencies and to monitor anti-platelet therapeutics. Each individual test contains 26 collagen coated capillary channels in parallel to for internal quality control purposes. Each chip is sufficient to run 2 samples simultaneously.
The PL chip for TTAS is designed for the diagnosis of primary hemostasis deficiencies and to monitor anti-platelet therapeutics. The PL Chip Reservoir allows blood to be safely loaded without risk of contaminating the PL Chip itself. A single blood reservoir is needed per test run.
The BAPA tube for TTAS is intended to be used for the collection, transport, and storage of blood specimens for use with the TTAS01 system. BAPA (Benzylsulfonyl-1-D-argininyl-prolyl-4-amidinobenzylamide) is an inhibitor of both Factor Xa and thrombin (Factor IIa). This allows for complete anticoagulation of blood without interfering, like sodium citrate based anticoagulation does, with physiological levels of calcium ions.