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Biochemistry of Rivaroxaban
- Molecular mass: 436 D
- Plasma half-life: 7-11h
- Peak plasma time: 2-4 hours after oral administration
- Bioavailability: 80-100%
- Composition: C19H18CIN3O5S
Clinical Aspects of Rivaroxaban
Rivaroxaban (Xarelto®) is an anticoagulant drug from the group of direct oral anticoagulants (DOAC). It is an oxazolidinone derivative. Different from the indirect anticoagulants (heparins, fondaparinux, danaparoid-sodium) DOACs do not need a co-factor (antithrombin) for their anticoagulant activity. If monitoring of anticoagulation therapy or an individual dose setting is necessary, a functional anti-factor Xa chromogenic assay (e.g. Chromogenix Coamatic® Heparin) should be used. In this assay, plasma spiked with Xarelto® has to be used for generation of a standard curve.
Clinical or Research use of Rivaroxaban
- Prevention of venous thromboembolic events (VTE) in adult subjects who have undergone elective hip or knee replacement surgery
- Prophylaxis of ischemic stroke and systemic embolism in subjects with non-valvular atrial fibrillation (NVAF)
- Acute and long-term treatment of subjects with deep vein thrombosis (DVT) and pulmonary embolism (PE)
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