The Total Thrombus formation Analysis System (T-TAS®) is an automated microchip flow chamber system used to quantify the process of thrombus formation under blood flow conditions. The T-TAS® 01 enables the ex vivo evaluation of overall hemostatic ability that more closely resembles in vivo conditions than other methodologies.
Technology Behind T-TAS
The T-TAS® 01 measures multiple integrated physical and physiologic properties of collagen- and shear force-stimulated platelets through the formation of the platelet plug during primary hemostasis. The T-TAS® 01 measures temporal changes in the pressure differential required to flow a specific volume of whole blood through the test flow channel. In this method, the patient sample is flowed through the collagen-coated test channels at a constant rate. As the platelets adhere, activate, and aggregate to the walls of the microfluidic channels and to other platelets, the channels begin to occlude. The pressure required for the same volume of blood to flow through the occluding channel is measured in real-time by highly sensitive pressure sensors.