Collagens constitute approximately one-third of body proteins and play fundamental roles during health and disease. Collagens are important for cellular growth, wound healing, tissue integrity, and healthy bones, skin, and cartilage. Disease can occur when collagen levels become deficient, excessive, or atypical. Organ fibrosis is a characteristic outcome of collagen accumulation that can cause organ damage in the liver, kidneys, lungs, skin, and heart. Due to the functional importance of collagen in basement membranes, collagens are influential during cancer progression. Atypical collagen synthesis promotes tumor cell invasiveness, cancer cell proliferation, and immunosuppression.
DiaPharma provides a dynamic collection of assays to quantitatively measure total collagen levels in a variety of tissues, including samples with low collagen levels. All types and forms of collagen, from any species, can be analyzed using a QuickZyme total collagen or hydroxyproline assay. Read more details…