Hemostasis Autoimmunity

Anti-Beta2 Glycoprotein I

Beta 2 Glycoprotein I (B2GPI) is a protein cofactor with natural anticoagulant properties and an affinity for negatively-charged phospholipids. Antibodies directed against B2GPI have been shown to be specific markers for thrombosis in individuals with systemic lupus erythematosus (SLE) and lupus-like disorders (antiphospholipid syndrome).

Anti-Cardiolipin

Anti-Cardiolipin antibodies (IgG, IgM, and IgA) are associated with arterial and venous thrombosis, thrombocytopenia, and recurrent fetal loss (antiphospholipid syndrome). They are frequently found in patients with systemic lupus erythematosus (SLE) and other autoimmune diseases.

Anti-Phosphatidylserine

Anti-Phosphatidylserine antibodies (IgG, IgM, and IgA) are associated with the same clinical manifestations as aCL. Phosphatidylserine is found in the membranes of platelets and endothelial cells, and participates in the coagulation cascade. Testing for antibodies to phosphatidylserine provides not only more clinically relevant results, but also additional information to assess the risk of thrombosis.

Anti-Prothrombin

Prothrombin is a protein associated with the coagulation system that has strong phospholipid binding properties. Elevated serum or plasma levels of anti-prothrombin antibodies may add valuable information in the laboratory assessment of antiphospholipid antibodies.

Lupus Anticoagulant (LA)