Coagulation Kits

ADAMTS-13

ADAMTS-13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13) is an enzyme (vWF-cleaving protease or vWF-CP) that specifically cleaves von Willebrand Factor (vWF) multimers, a large protein involved in blood clotting. It is secreted in blood and degrades large vWF multimers. If the activity of ADAMTS-13 is decreased, unusually large vWF multimers may accumulate within blood causing thrombosis due to platelet aggregation, which in turn may lead to TTP (thrombotic thrombocytopenic purpura). Differentiation of TTP from other thrombotic microangiopathies (TMA) is challenging. Read more…

Antithrombin

Antithrombin (AT) or Heparin Cofactor I is the major inhibitor of blood coagulation and is essential for effective heparin therapy. By inhibiting the coagulation proteases, especially thrombin, FXa and FIXa, AT prevents uncontrolled coagulation and thrombosis. Antithrombin deficiency is associated with a high risk of thromboembolic disorders. Read more…

APC Resistance (Factor V Leiden)

Activated Protein C (APC) is a regulator of the coagulation cascade, by specifically inactivating factors Va and VIIIa, in the presence of phospholipids and calcium.

Activated Protein C Resistance is tested by using a clotting method performed with or without Activated Protein C. Read more…

Direct Thrombin Inhibitors (DTI)

C1-Esterase Inhibitor (C1-INH)

The C1-esterase inhibitor (C1-INH) is a regulatory protein that functions as an inhibitor of several serine proteases in the complement system, the kallikrein-kinin system, the coagulation cascade and in fibrinolysis.

Factor IXa (FIXa)

Factor VIII (FVIII)

Factor VIII is a high molecular weight plasma protein which serves as a cofactor to factor IXa in its activation of factor X to factor Xa. Deficiency of factor VIII causes a severe bleeding disorder, hemophilia A. The severity of this bleeding disorder is inversely related to the factor VIII concentration. Read more…

Factor IX (FIX)

Factor IX (Christmas factor) is one of the serine proteases of the coagulation system. Factor IX protein deficiency causes hemophilia B. Read more…

Factor X (FX)

Coagulation Factor X (Stuart Prower Factor, FX) is a vitamin K dependent protein produced by the liver. It has a central position in the coagulation cascade. Factor X is activated both by the extrinsic and intrinsic systems before exerting its effect on the conversion of prothrombin to thrombin. Read more…

Factor XIa (FXIa)

Factor XI (plasma thromboplastin antecedent) is a serine protease activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself. FXI is a member of the coagulation “contact pathway” (which includes HMWK, prekallikrein, factor XII, factor XI, and factor IX). Read more…

Factor XIII (FXIII)

Factor XIII (also know as fibrin stabilizing factor or Laki-Lorand factor) is an enzyme of the blood coagulation system that crosslinks fibrin. When thrombin has converted fibrinogen to fibrin, fibrin forms a proteinaceous network in which every E-unit is crosslinked to only one D-unit. Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor. Read more…

Fibrinogen

Fibronectin

Heparin

Heparin is an anticoagulant that prevents the blood clots. Heparin does not break down clots that have already formed (unlike tissue plasminogen activator) but allows fibrinolysis to work normally to break down clots.

Diapharma’s heparin kits are for the chromogenic determination of UF and LMW heparin in human plasma, and measure the ability of heparin to catalyze the inhibition of FXa by antithrombin. Read more…

Microparticles

Prekallikrein Activator (PKA)

Protein C

Protein C is a vitamin K dependent plasma protein which plays an important role in the anticoagulant regulatory mechanisms. It circulates as a zymogen and is converted to an active serine protease, activated Protein C (APC), by the action of thrombin in presence of thrombomodulin. APC regulates the coagulation system by proteolytic cleavage and inactivation of activated factors V and VIII. Hereditary and/or acquired Protein C deficiency has been shown to be a risk factor for development of venous thrombosis. Read more…

Protein S

Protein S (S-Protein) is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium. Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP).

Free Protein S plays a role in the anti-coagulation pathway, where it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa. Read more…

Prothrombin

Read more about prothrombin…

Thrombin Generation

Read more about thrombin generation…

Vitronectin

von Willebrand Factor (vWF)

The diagnosis of von Willebrand Disease (VWD), probably the most common congenital bleeding disorder, requires a number of special tests at the laboratory level. The measurement and comparison of von Willebrand Factor Antigen (VWF:Ag), VWF Activity and Factor VIII (FVIII) levels in plasma aid in the differentiation of quantitative defects (type 1 or type 3) or qualitative defect (type 2) of VWF and therefore to diagnose the different types of VWD.

Learn more about von Willebrand Factor and von Willebrand Disease.