Multiplate® vWF reagent is a research reagent kit containing vWF (von Willebrand Factor), derived from a FVIII concentrate with a high concentration of vWF, for use with the Multiplate® Platelet Function Analyzer. The RISTOtest in Multiplate® is sensitive for von Willebrand research. This vWF reagent can be used when researching GPIb receptor defect (Bernard-Soulier Syndrome, BSS), aspirin effects, Glanzmann thrombasthenia or vWD.
Reagents, Storage and Stability
- MP0548: vWF reagent, bag, 1 x 1.0 ml, lyophilized (7.5 U/ml) with 5 micro test tubes for aliquotation. The reagent is stable until the expiry date printed on the vial label when stored at 2-8°C. If reconstituted reagent is not transferred into micro test tubes, the original vial should be stored in an upright position.
In RISTOtest high a high concentration of ristocetin (0.77 mg/ml) is applied, which normally induces a strong platelet aggregation. Attenuated aggregation in RISTOtest high can be based on a deficiency of GpIb receptors or vWF. In RISTOtest low a lower concentration of ristocetin (0.2 mg/ml) is applied which normally does not induce a strong aggregation response. A higher than expected aggregation in RISTOtest low may indicate an enhanced aggregation tendency of vWF (vWS type IIb).