Thrombodynamics® TDX is a reagent and consumable kit used to perform measurements of spatiotemporal dynamics of fibrin clot formation in blood plasma samples on the Thrombodynamics® T2F and T2T Analyzers.
- Reagent I. 10 Neutral Plastic Tubes:
Contains a lyophilized mix of a contact pathway activation inhibitor and additives.
Reagent I is ready to use as packaged
- Reagent II. 10 Blue Plastic Tubes:
Contains a lyophilized mix of calcium salt and additives
Reagent II is ready to use as packaged
- Measurement Cuvette. 5 Individually wrapped cuvettes:
A plastic vial with 2 thin channels for plasma samples
Measurement cuvettes are ready to use as packaged
- Activating Insert. 5 Individually wrapped inserts
A plastic comb with immobilized tissue factor in its bottom end faces
Activation insert is ready to use as packaged
In the Thrombodynamics® test kits, protein tissue factor (TF) located on the end face of the activating insert mimics the physiology of a damaged vasculature or inflammation. A basal level of active serine protease Factor VIIa binds this TF to become a fully functional protease that eventually leads to fibrin polymerization and clot formation. The on board dark-field camera images this fibrin polymerization over time allowing for quantification of multiple parameters to blood coagulation using special mathematical techniques.