X9222 Haematex Tubes

Inhibitor Tubes by Haematex (Sample pack)

$0.00

  • Catalog #: X9222-S
  • Packaging: 12 tubes
  • Type: Tubes
  • Use: Research Use Only (RUO)

Direct oral anticoagulants (DOACs) are available as rapidly-dissolving 500 nanogram “dots” on disposable plastic tubes. The dots dissolve within 10 minutes into 1ml of fluids such as blood, plasma or urine, thereby transferring the compound into samples. Inhibitor dots in tubes makes it easier to mix and store the sample. Plasmas treated using Inhibitor Tubes may be used as positive controls in clotting, chromogenic or other assays. Dilutions can be prepared in pooled normal plasma, blood or other fluids to set up calibration curves.

Haematex has a new supported film technology adaptable to any potent, stable agent. It allows a library of compounds to be held as a flat collection rather than in vials, thereby allowing for more easy transport and storage. Dabi-like, edoxa-like, betrixa-like, riva-like and apixa-like compounds are available. Also, heparin (0.2 Iu). All ‘dots’ are color-coded for recognition. These customized dots can be manufactured on demand based on your laboratory needs, please see the form below to order.

Samples prepared using Inhibitor Tubes can be used for checking the efficacy of DOAC-Stop™. This agent extracts DOACs from test samples relatively specifically. Thus, samples prepared with DOACs from Inhibitor Tubes should show restoration of original test results after treatment with DOAC-Stop™. Samples prepared with Heparin Dots should not be modified by DOAC-Stop™.

Research use only. Not for use in diagnostic procedures.

Background

Inhibitor Tubes provide a pre-determined quantity of a coagulation inhibitor such as a DOAC (dabigatran, apixaban, rivaroxaban, edoxaban and betrixaban) or heparin for delivery to a blood, plasma or urine sample on a plastic dipstick. They allow laboratories to prepare inhibitor samples at any concentration in any biological fluid for use in research, teaching or other purposes.

DOACs and other anticoagulants are usually provided in freeze dried normal plasmas for reconstitution and use as calibrators or in quality control. Inhibitor Tubes provide an alternative way for laboratories to access such agents for multiple uses. DOACs are provided in 500ng quantities; heparin as 0.3Iu, dried in a stabilizing and rapidly soluble film on a narrow dispenser tube. Each inhibitor tube is colored for simple identification as shown below. The binding agents in the tubes total 200ug and have insignificant effect on clotting or other tests when dispersed in 1ml of plasma or blood. Each tube is identified by a label showing lot number, expiry date and inhibitor quantity. Each dot dissolves within 2 minutes after being immersed in a fluid.

Plasmas treated with Inhibitor Tubes may be used as positive controls in clotting, chromogenic or other assays. Dilutions can be prepared in pooled normal plasma, blood or other fluids to set up calibration curves.

Samples prepared from Inhibitor Tubes can be used for checking the efficacy of DOAC Stop™. This agent extracts DOACs from test samples relatively specifically. Thus, samples prepared with DOACs from Inhibitor Tubes should show restoration of original test results after treatment with DOAC Stop. Samples prepared with Heparin Tubes should not be modified by DOAC Stop.

Instructions for Use

  1. Take the appropriate inhibitor tube from its storage container.
  2. Add 1 ml of citrated blood plasma/urine into each tube.
  3. After standing for 5 minutes, mix thoroughly.
  4. The fluid sample will then contain the targeted value of the inhibitor in 1 ml.

Method for adding an inhibitor to a liquid sample.

Application

Plasmas treated with Inhibitor Tubes may be used as positive controls in clotting, chromogenic or other assays. Dilutions can be prepared in pooled normal plasma, blood or other fluids to set up calibration curves. Consensus values can be established from interlaboratory testing surveys.

Samples prepared from Inhibitor Tubes can be used for checking the efficacy of DOAC Stop (1). This agent removes DOACs from test samples relatively specifically (2). Thus, samples prepared with DOACs from Inhibitor Tubes should show restoration to original test results after treatment with DOAC-Stop™. Conversely, results on samples prepared with Heparin Dots should not be modified by DOAC-Stop™.

Precautions

Inhibitor Tubes are strictly for in vitro use. If appropriate test results are not as expected by Inhibitor Tubes, apply appropriate clotting, chromogenic anti factor Xa or anti thrombin assays to obtain specific results. Contact your distributor or manufacturer for technical support.

Store at 2-8°C. Keep dry. Do not use after the expiry date indicated on the label. Treat all clinical material as potentially infectious and dispose of in accordance with local operating regulations. For further information, please refer to Safety Data Sheet and Product Information.