Technozym® vWF:Ag Calibrator is a calibrator set including 5 x 0.5 ml calibrators for Technozym® vWF Antigen.
The von Willebrand Factor (vWF) is a large, multifunctional glycoprotein, occupying a key position in primary hemostasis. It has a multiple structure with several functions:
- It is the carrier protein for Factor VIII in plasma; it forms a complex and thus protects Factor VIII from early proteolytic decomposition.
- It acts as a mediator for platelet aggregation by attaching itself to platelet membrane receptors (GP Ib and GP lIb/IIIa) following previous platelet activation.
- It plays a part in primary hemostasis by acting as a mediator between adhesioned platelets and the subendothelium (lesioned vascular wall). The von Willebrand Syndrome (vWS) is the most frequently occurring hemorrhagic disease; it may be hereditary as well as acquired, caused by quantitative or qualitative defects of the vWF.