Just Positive™ Prekallikrein Activator (PKA) Control product is a borderline positive control for assays of Prekallikrein Activator in biological fluids.

The method for the determination of Prekallikrein Activator (PKA) in human plasma derived products is based on the activation of a prekallikrein preparation from human plasma. The PKA present in the sample activates plasma prekallikrein to plasma kallikrein, which then hydrolyses a chromogenic peptide substrate for plasma kallikrein. The amount of colour generated is monitored spectrophotometrically and is directly proportional to the amount of PKA present in the sample.

Just Positive™ Prekallikrein Activator (PKA) control can be used as a borderline positive control for the assay of PKA.

5 x 0.5ml vials composed of Just Positive™ Prekallikrein Activator (PKA) Control is prepared from a plasma fraction containing PKA.

The expiry date printed on the bottle labels refers to the storage of unopened bottles stored at 2 to 8°C.


Additional Material Required

Pathway Diagnostics Prekallikrein Activator (PKA) assay kit, (shown below), or an “in-house” PKA assay:

  • PW30100 Prekallikrein Activator (PKA) assay kit 90 tests
  • PW301EP Prekallikrein Activator (PKA) assay kit 90 tests

Test standardization and limitations

The production and standardization of Just Positive™ Prekallikrein Activator (PKA) Control is controlled by the use of the 2nd International Standard for PKA.

The level of PKA in Just Positive™ Prekallikrein Activator (PKA) Control is batch specific and assigned using the Pathway Diagnostics Prekallikrein Activator (PKA) assay kit. The control is intended as an accuracy control of the Pathway Diagnostics Prekallikrein Activator (PKA) assay, but can also be used as a control in “in-house” PKA assays.

The batch specific control ranges assigned using the Pathway Diagnostics PKA test are shown in the table printed on the reverse side of the insert packaged with the product.