New Biomarkers for Liver and Kidney Toxicity Studies

Posted: September 5, 2018

New Biomarkers for Liver and Kidney Toxicity Studies

Diapharma is your source for

liver & kidney toxicity assays

Defend the safety of your drug candidate

with new biomarkers

Reduce risk of unnecessary costs by preventing large clinical trials with indeterminate liver safety concerns

  • Prevent unnecessary withdrawal or clinical hold promising new drug candidates
  • Most importantly, prevent delay of new medications to the market

The use of new biomarkers and new models can increase liver specificity and provide mechanistic information.

The M30 Apoptosense® CK18 research kit specifically detects caspase-cleaved CK18 (ccCK18) released from apoptotic tumor cells.

 

Research Use Only in the U.S. and Canada

 

BiomarkerELISA kits for study of
Caspase-Cleaved Keratin 18
(ccK18: M30 ELISA)
Liver and Kidney Cell Apoptosis
Keratin 18
(cleaved and uncleaved: M65 ELISA)
Liver and Kidney Cell Apoptosis and Necrosis
Hyaluronic Acid (HA)Liver Fibrosis and Loss of Liver Function
α-GSTDrug Development, Acute Kidney and Liver Injury, Highly Sensitive & Specific Biomarker
Collagen IVChronic Kidney or Liver Injury Biomarker Complementary to α-GST & π-GST
Adiponectin, Proinsulin, & LeptinDiabetes, Metabolic Syndrome, Endocrine Factors
C-Reactive Protein (CRP)Liver Disease and Failure, Fibrosis, Cancer
Cystatin CKidney Disease, Chronic Liver Disease, Cirrhosis, Cancer
Fatty Acid Binding Protein-4Diabetes, Fatty Liver Disease
Fibroblast Growth Factor-19 (FGF-19)Metabolic Syndrome, Fatty Liver Disease, Insulin Resistance, Cancer
Fibroblast Growth Factor-21 (FGF-21)Diabetes, Fatty Liver Disease, Cancer
Galectin-3Fibrosis, Cancer, Apoptosis
Lipocalin-2 (NGAL)Acute Kidney Injury, Kidney Disease
Plasminogen Activator Inhibitor-1 (PAI-1)Fibrinolysis, Metabolic Syndrome, Kidney Disease
von Willebrand FactorLiver Fibrosis & Cirrhosis

 

New Biomarkers for Liver and Kidney Toxicity Studies

Keratin 18

M30 Apoptosense ELISA
M65 EpiDeath ELISA
M65 ELISA
M30 CytoDeath ELISA

  • Cell death assays for detecting hepatoxicity during drug development

Research use only in the U.S. and Canada

 

New Biomarkers for Liver and Kidney Toxicity Studies

New Biomarkers for Liver and Kidney Toxicity Studies

ML-00-00373Rev01