Now Available! M65 EpiRat™ ELISA for drug safety studies

M65 EpiRat™ ELISA

New Tool for Translational

Drug Safety Studies

Research Lots Available for Evaluation

The new edition to the our product line, M65 EpiRat™ ELISA, is optimized as a rat specific assay and represents the final piece of the puzzle for the complete K18 portfolio. This means Diapharma offers a full line of valuable products for all stages of drug development, from discovery and pre-clinical phase up until clinical application of the drug.

The M65 EpiRat™ ELISA is based on the M5 and M6 antibodies, which bind to the biomarker Keratin-18 (K18). The concentration of K18 reflects the amount of overall cell death, both apoptosis and necrosis, in K18 positive cells. Levels of K18 are commonly elevated when the liver endures damage, through disease or toxicological effects.

Toxicology

The M65 EpiRat™ ELISA can be used in toxicological studies. As rodent species are commonly used globally in traditional toxicology testing guidelines to predict human health toxicity outcomes, the M65 EpiRat™ will help by quantifying the amount of cell death in hepatocytes to assess liver toxicity.

Research

In pre-clinical studies, the M65 EpiRat™ ELISA can be used to analyse the effect of drugs in development, for example for new compounds in Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH).

M65 EpiRat™ ELISA’s unique characteristics:

• Rat-specific measurement of total cell death in K18 positive cells – quantifies hepatocyte cell death to assess liver toxicity
• Sensitive serum biomarker for quantification of K18 in rat serum and plasma samples
• Convenient ready to use ELISA format and can be split up for use at several occasions.

We are very happy to welcome the M65 EpiRat™ ELISA to the Diapharma product line!

Research use only in the U.S. and Canada