Next Generation Assays for Hemophilia A & B Gene Therapy Research

Posted: May 7, 2020

specialty coagulation products

Diapharma is your source for Chromogenic Assays and Thrombin Generation Testing in Hemophilia Gene Therapy Studies

hemophilia

Easily and Accurately Measure FVIII activity in gene therapy studies

  • COAMATIC® FVIII (K822585)

  • COATEST® SP FVIII (K824086)

  • COATEST® SP4 FVIII (K824094)

Contains bovine factor reagents

coamatic factor viii

Assay FIX in hemophilia B gene therapy studies:

ROX Factor IX (900020)

Bringing Chromogenic Factor IX determination into the next era

Research use only in the U.S. and Canada.

factor ix assay kit

CEVERON® TGA RB Kit (5006011)

Thrombin Generation Assay for Hemophilia Studies

  • With low concentration of phospholipid micelles and rhTF for researching global response to gene therapy preparations

Automated on Ceveron® t100 / Ceveron® s100

  • Optimized for the fully automated measurement of Thrombin Generation on Ceveron® t100 and Ceveron® s100
  • Easy as a routine assay
  • Precise
  • Fast
  • Up to 36 samples in a single run

Research use only in the U.S. and Canada.

More Information:

FACTOR VIII

For chromogenic determination of FVIII levels in plasma and concentrates

COAMATIC® FVIII (K822585)

  • Sensitive and reproducible – measure FVIII in moderate to severe hemophilia A patients
  • Suitable to measure b-domain deleted FVIII and extended half-life recombinant replacement products
  • Suitable for monitoring new, longer acting agents
  • No need for factor deficient plasma
  • Instrument applications available
  • FDA cleared for diagnostic us

COATEST® SP FVIII (K824086)

  • Ideal for measuring FVIII concentrates
  • 1% BSA in accordance with recommendation for dilution of highly purified FVIII concentrates
  • Conforms to EP FVIII potency test requirements
  • FDA cleared for diagnostic use

COATEST® SP4 FVIII (K824094)

  • Coatest SP FVIII factor reagent divided into 4 vials, for smaller volume testing
  • FDA cleared for diagnostic use

TECHNOCHROM® FVIII:C* (5344101)

TECHNOCHROM® FVIII:C FOR CEVERON ALPHA* (5344103)

  • Excellent reagent stability, accuracy and precision
  • Four reference standards (cal. against WHO)
  • Assay range 0-200%

FVIII INHIBITOR REAGENT KIT* (5152005)

FVIII INHIBITOR REAGENT KIT HCV NEG.* (5152009)

Reagent kit for the determination of Factor VIII Inhibitor according to Bethesda

  • Improved specificity in the lower range of antibody detection due to to dilution with buffered normal FVIII plasma (1 IU.FVIII/ml)
  • Contains FVIII INH plasma as positive control and FVIII INH free plasma as negative control

FVIII INHIBITOR PLASMA* (5159008)

FVIII INHIBITOR PLASMA HCV NEG.* (5159010)

FVIII DEFICIENT PLASMA, IMMUND.* (5154002)

FVIII DEFICIENT PLASMA, NATIVE* (5154007)

 

FACTOR IX (FIX)

Bringing chromogenic Factor IX determination into the next era

ROX FIX* (900020)

  • Highly sensitive chromogenic assay for Factor IX activity in plasma or concentrates
  • Study of new FIX variants and Hemophilia B gene therapy
    – Does not overestimate FIX activity compared to certain aPTT reagents in qualifying FIX variants
  • Reliable potency assignments of recombinant and plasma-derived FIX
  • FIX deficient plasma not required

* Research Use Only in the U.S. and Canada. Not for diagnostic procedures.

Visit diapharma.com for our complete line of chromogenic substrates, inhibitors, assay kits, proteins, enzymes, and more.

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