Gordon Research Conference (GRC) – Cellular & Molecular Mechanisms of Toxicity: Integration of Emerging Technologies in Mechanistic and Translational Toxicology

Event Date: August 11 - 16, 2019

Event Location: Proctor Academy, 204 Main Street, Andover, NH 03216

 

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toxicity assaytoxicity assayAbout Gordon Research Conference – Cellular & Molecular Mechanisms of Toxicity: Integration of Emerging Technologies in Mechanistic and Translational Toxicology

This GRC will be held in conjunction with the “Cellular and Molecular Mechanisms of Toxicity (GRS)” Gordon Research Seminar (GRS).

The Cellular and Molecular Mechanisms of Toxicity GRC is a forum for showcasing the latest unpublished and innovative advances in mechanistic toxicological research and its translational application to safety assessment, risk management and public health policy. The program highlights innovations and challenges in mechanistic toxicology including the human exposome, big data and quantitative systems modeling, translational medicine and target organ toxicity, microphysiological systems, nuclear receptor targeting, and emerging technologies and alternative methods in risk assessment. Highlighted speakers have been selected to represent diverse perspectives on environmental, industrial, and pharmaceutical toxicology with a special session spotlighting rising young investigators. A distinctive “Power Hour” event will discuss the challenges women face in sciences, mechanisms to support their professional growth and offer an opportunity for feedback and professional advice from peers and leading mentors in an informal atmosphere.

Daily poster sessions will provide participants the opportunity to present their latest, unpublished work in an atmosphere that fosters a relaxed dialog and idea sharing. A select number of abstract submissions will also be chosen for “late-breaking” short oral presentations. A key to the success of the GRC format is the networking opportunities that occur at meal times and during daily social/recreational activities. These exchanges have often led to long-lasting scientific collaborations, connections and career opportunities.

A Gordon Research Seminar (GRS) will precede this GRC conference. The GRS is organized and run by graduate students and fellows. It provides an expanded opportunity for trainees and young scientists to be exposed to cutting-edge science and to network with their future colleagues. All GRS attendees are also encouraged to apply to this GRC conference.

Gordon Research Conference Topics Include

  • A Framework for Toxicology at a Grand Scale
  • Using the Exposome to Study Adverse Events at a Population Level
  • Analytics for Interrogating Exposomes and Phenomes in Disease and Health
  • Diverse Tissues, Diverse Responses: Delving into Organ Toxicity
  • Evaluating Diet-PFAS Interactions in Models of Obesity and NAFLD
  • Environmental PPARγ and RXR Ligands: Selective Agonists that Disrupt Bone and Adipose Homeostasis
  • Flavoring Chemicals and Pulmonary Cellular Toxicological Responses
  • Advances at the Interface of Toxicology and Medicine: Toward Prevention and Treatment of Toxicant-Mediated Disease
  • From the Most Dangerous Dioxin to the Most Profitable Weed Killer: Environmental Risks of Multiple Myeloma
  • MicroRNA Expression as a Biomarker of Acute Lung Injury in Humans
  • Mechanisms of Toxicant Associated Steatohepatitis in Translational Studies
  • Nuclear Receptors Old and New: Novel Pharmacological and Toxicological Targets
  • Nuclear Receptors in Drug Discovery
  • Targeted Nuclear Receptor Modulation of the Gut-Liver Axis in Xenobiotic Biotransformation
  • Hepatocyte Nuclear Factor 4 Alpha: A Novel (and Often Ignored) Toxicant Target
  • Applications of Microphysiological Systems in Toxicological Research
  • Microphysiological Systems, Mechanisms of Action, and Chronotoxicology
  • Translational Applications of Tissue Chip Technologies
  • Application of Organs on Chips in Pharma Industry: The Need, Gaps and the Vision
  • Genetic and Epigenetic Responses to Hydrogen Sulfide Exposure
  • Environmental Exposures and Stem Cell Reprogramming: Understanding Racial Disparities in Triple Negative Breast Cancer
  • Epigenetics and Regulatory Toxicology
  • Testing Beyond Animals: Pushing the Frontiers in Safety Evaluation
  • In Vivo 5-Day Transcriptomics Approach to Estimating Points of Departure
  • From Plates to Human: Validating Assays with Investigative Toxicology
  • Bridging the Gap with RISK21: Risk Assessment in the 21st Century
  • Emerging Technologies and Alternative Testing Strategies
  • Using 3D Organotypic Cultures to Model Cancer Biology and Treatment Response
  • Therapeutic Strategies via Genome Engineering: New Approaches and Challenges
  • Rewiring of the 3D Genome in Inorganic Arsenic-Mediated Carcinogenesis
  • Keynote Session: Utilizing Big Data and Quantitative Systems Modeling to Derive Outcomes
  • Utilizing Big Data and Systems Modeling to Derive a Widely Applicable Predictive Toxicogenomics Space Tool
  • Quantitative Mechanistic High Content Data for Predictive Systems Toxicology Modelling

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