What is the mode of action for the Peviva M30 CytoDeath™ ELISA?

M30 CytoDeath™ ELISA is a sandwich ELISA based on two mouse monoclonal antibodies, M30 and M6. The M30 antibody recognizes a neo-epitope in the C-terminal domain of keratin 18 (amino acids 387-396: K18Asp396-NE), exposed after cleavage by multiple caspases during apoptosis. The M6 antibody is used as capture antibody in the ELISA. Caspases that are capable of cleaving K18 to generate this M30 neo-epitope include in addition to caspase-3, also caspase-6, -7, and -9.