Cell death is the biological process in which cells stop functioning due to the natural process of old cells dying and being replaced by new ones (apoptosis), or disease, injury, infection, or the death of the organism (necrosis). Read more…

THE LIVER, KERATINS AND DEATH

An association between liver disease, keratins, and liver cell death has been known for over a hundred years. In fact, in 1911 F.B. Mallory observed that “The so-called alcoholic type of cirrhosis is characterized by a peculiar hyaline degeneration of the cytoplasm of the liver cells preceding necrosis.” Alcoholic hyaline bodies that occur characteristically in abundance in the diseased livers of alcoholic patients became known as Mallory bodies (MBs) and Mallory-Denk bodies (MDBs), which were eventually found to be characteristics of other liver diseases as well. Read more…